dacF [2017-06-27 18:30:40]

penicillin-binding protein I, D-alanyl-D-alanine carboxypeptidase

Locus: BSU23480

Isoelectric point: 9.91

Molecular weight: 43.13 kDa

Protein length: 389 aa

Gene length: 1167 bp

Function: carboxypeptidase

Product: penicillin-binding protein I, D-alanyl-D-alanine carboxypeptidase

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Penicillin-binding proteins
• Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other
• Groups of genes → Secreted proteins

Gene

Coordinates: 2,445,094 → 2,446,263

The protein

Catalyzed reaction/ biological activity

• modifies degree of cross-linking of glycan strands in peptidoglycan

Protein family

• peptidase S11 family (according to Swiss-Prot)

Paralogous protein(s)

• DacA

Structure

• 4K91 (from Pseudomonas aeruginosa, 38% identity)

Expression and Regulation

Operons

• Genes: dacF-spoIIAA-spoIIAB-sigF
  Description: PubMed

  Sigma factors

  • SigF: sigma factor, PubMed, in SigF regulon
  • SigG: sigma factor, in SigG regulon

  Regulatory mechanism

  • AbrB: repression, PubMed, in AbrB regulon

  Regulation

  • spoIIAA: expressed early during sporulation
  • strongly repressed in the presence of salt (1.2 M NaCl) PubMed

References

Reviews

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Original publications

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